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Alpha Male Nation | January 16, 2018

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The Work Procedure of the Male Pill - Alpha Male Nation

The Work Procedure of the Male Pill and Sperm

What is the male pill?

The Pill – these are two words that go hand in hand when it comes to birth control. However, even after 50 years of the introduction of oral contraceptives, these remain a birth control option only for the women.

As per reports, in the US, around 17.5% women between ages 15 and 44 on birth control are into the effective use of oral contraceptives. The U.S. Centers for Disease Control or CDC has brought forward this report. Vasectomies and condoms remain the only birth control options for men.

They have not changed and remained the same as they have for centuries. Even if 5% to 10% men used oral contraceptives, it would be of good help in limiting population growth. This has been confirmed by Ilpo Huhtaniemi, a recognized professor of Reproductive Endocrinology at the Imperial College London.

The young men generally prefer condoms while vasectomies are for the older men. This is due to the permanence linked with vasectomies. Huhtaniemi says that there should be something for men so that they can take the same responsibility like the women. In the recent times, some hope has been identified in this field or on this subject.

Disturbing the Hormones

During a research on male oral contraceptive, one of the earliest stages was controlling sperm production. This was done by targeting the testosterone hormone. Increasing the levels of testosterone within the body can result in the decreased release of hormones required for producing sperm.

The male pituitary gland will gradually release less sperm producing hormones with increased levels of testosterone. A series of clinical trials on this subject showed unstable effectiveness from a 60% to 90% reduction in fertility. This has been confirmed by Huhtaniemi. However, there were side effects associated with this and they were depression and weight gain.

Huhtaniemi further said that there was not much suppression. He is of the belief that stopping the sperm directly is a way forward. This is namely by targeting any one of the hundreds of proteins and genes involved in sperm development. As per Huhtaniemi, if researchers get hold of a drug for blocking the proteins, it would be the perfect contraceptive.

Stop the Sperms from Swimming

Calcineuron is a protein that helps the sperms in swimming and breaking through the membrane of female eggs helping the sperm fertilize. This protein was discovered by Haruhiko Miyata and his colleagues researching on this subject at Osaka University, Japan. Haruhiko Miyata conducted a study on mice and published it in the month of October in 2015.

The team further concluded that when the genes behind Calcineuron were blocked, it resulted in infertility in the mice. The effects have been visible in the mice just within five to six days post treatment. It was concluded that the presence of these similar proteins in human beings make it a probable option.

Effects were completely reversible because fertility was successfully restored post stopping the treatments. This might result in the development of a fully reversible male contraceptive, Haruhiko wrote in one paper.

However, the scientist also warned people of the challenges involved with these treatments. He said that there were great challenges involved in using these treatments for controlling sperms in large quantities.

He also said that the chances of use of these treatments by human beings are still a decade away. The main reason behind this delay was the biology. He said that at every heart beat a man produces thousands of sperm.

Preventing Fusion

There are many studies that have focused on the varied phases of sperm fertilization and production. As per one study published in the year 2015, there was a process required for fusion of sperm with egg.

This was during the fertilization procedure. John Herr was the name behind the research. He was the professor of cell Biology and Biomedical Engineering at University of Virginia. It was John Herr who found that a small filament stabilized sperm during its fusion with an egg. This fusion could be prevented by blocking the procedure of stabilization.

This would further help in preventing pregnancy. Herr said that at present there are many more things that his team needs to uncover. He said that it was too early. He and his team needed more time to understand the system involved in the fertilization procedure. They also need to understand the process of blocking the formation of this small filament.

A pill meant or men might be decades away but Huhtaniemi always has this hope. He is convinced that a certain observation on some non-hormonal being could give a breakthrough. It would actually stop the sperms from swimming in the first place.

The Vasalgel

An all new and promising development in the field of male contraception is an injection called Vasalgel. It basically involves injecting a polymer into the sperm carrying tubes for blocking sperm while they are released.

This injection actually works in the form of vasectomy but without the slice involved. Vasalgel is basically a kind of sticky gel which goes into the sperm carrying tubes and works by filtering out sperms. Elaine Lissner states this.

He is the executive director of Parsemus Foundation which is the medical research foundation working behind the introduction of Vasalgel. In India, a polymer same as Vasalgel is on trial and it is called RISUG. RISUG is basically a medical tool and not a drug and therefore it is much more possible. Lissner confirms this.

Vasalgel is injected in a certain location same as the slice during vasectomy. Vasalgel gives way to fluids while blocking sperm. Sperms which are backed-up like this are reabsorbed by the body.

Added advantage of Vasalgel is that it disintegrates immediately after a second solution is used for breaking down the obstacle. This is something that makes the entire procedure of using Vasalgel completely reversible.

This reversibility is proved in trials on rabbits. However, recent trials on baboons did not show any reversibility. At present, the team is working on the challenges so that it can be trialed on human beings in the year 2016. According to Lissner, successful reversibility is the key to making the world-changing.

One important factor to be considered with the use of Vasalgel is that it will also involve minor surgery. This surgery will be in place for pulling out the sperm carrying tubes and injecting the gel.

This is because if the sperms are reabsorbed by the human body, the possibilities of immune reaction are quite high. This would leave men infertile even after reversal. Lissner is completely confident of the fact that Vasalgel would overcome the major challenges involved. It would be ready for use within the next four to five years.