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Alpha Male Nation | January 18, 2018

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Specific Protein Enhances the Probabilities of Male Contraception - Alpha Male Nation

Specific Protein Enhances the Probabilities of Male Contraception

Newly Discovered Sperm-Specific Protein Enhances the Probabilities of Male Contraception

Women have several contraceptive options to depend on starting from patches to pills to IUDs. However, there is still no new option of contraception available for the men ever since vasectomy.

Vasectomy was a method introduced for sterilizing males at the end of the 19th century. Vasectomy is an irreversible contraceptive method for men. This means that the effects produced by this method cannot be reversed.

Men undergoing this procedure cannot get fertile post treatment. There is no reversible method available for male contraception ever since the introduction of the condom. Is a male contraception method really required?

The answer to this question is a definite Yes. This is because couples in the recent times are trying to balance their responsibilities when it comes to reproduction. Men, who have the power of the paternity test, have added advantages when it comes to keeping their sperm in line.

Scientists and researchers working on this subject have come up with a kind of sperm-specific protein. They are of the view that by depleting this sperm-specific protein they can render the men infertile. They have come to this conclusion through the results of their tests conducted on mice.

The men who will be rendered infertile with the depletion of this protein will still have the capability of sex. These findings could result in the discovery of a probable male contraceptive in the near future.

Options for Women, Contraception

When contraceptive pills for women were introduced during the 1960s, they created a sense of freedom and empowerment for women. Having sex transformed into an enjoyable activity because the fear of getting pregnant suddenly vanished.

The added advantage of skipping menstruation allowed women to wear their whites without any worry. The contraceptive pill for women was a tiny miracle that changed lives. At present, around 17.5% women between 15 and 44 years of age use contraceptive pills to avoid pregnancy.

However, there are many women who are not able to take pills because of medical concerns. Women with high blood pressure cannot take contraceptive pills and even the ones who have increased chances of heart problems.

Women have many options when making the choice of birth control. However, it is still scary for women to have injections or get metal coils inserted for avoiding pregnancy. Contraception is a subject that women take very seriously right from a very young age. Women are also advised to be safe all the time.

What about Male Contraception?

When it comes to male contraception, there are very few options for the men. Young men cannot consider vasectomy or abstinence in anyways. This further results in the complete absence of male contraception options, especially for the young men.

While the young girls are given long lectures about contraception in school, boys are just told to use a condom. Contraception is a responsibility or to say a necessity for women.

But, why there is no method that can help the men in sharing this responsibility? With revolutionary options set to be launched in the 21st century, male contraception is a hot topic these days.

The Sperm Factor

For ages, men have always wanted alternatives to condoms in contraception. In fact, men do face the inability of taking responsibility is because they do not have wide choices in contraception. Birth control pills to be used by women have always been there, but what about male contraception?

Studies conducted on this subject have concluded that calcineurin is a protein that helps in activating immune cells. This protein also plays a crucial role in male fertility. Nevertheless, the presence of different forms of this protein in testes had made it challenging to determine the purpose of each.

The different forms of this protein are called isoforms. However, researchers have recently found good evidence that this protein isoforms contain PPP3CC. PPP3CC is a catalytic subunit while PPP3R2 is a regulatory subunit. PPP3R2 is only found in the cells, resulting in the formation of sperm. PPP3R2 joins with PPP3CC for forming calcineurin complex during the production of sperm.

Masahito Ikawa from Osaka University along with his colleagues examined these sperm-specific calcineurin subunits. Upon examination, they found that when they knocked out the gene for PPP3CC subunits in mice, it created a mutation.

This mutation was created in calcineurin which subsequently made the men infertile. However, they still had the ability to have sex. The sperm which was PPP3CC depleted was not able to swim very well. It also lost its ability to penetrate into the membrane of the female egg. The sperm was not able to fertilize eggs.

The Final Point

A post examining sperm-specific calcineurin subunits, Ikawa’s team worked on sperm motility. There are minimum two types of immunosuppressant drugs used post organ transplants. These drugs can inhibit calcineurin.

Proper treatment using these drugs for five to six days can render the male infertile. The team concluded that using the immunosuppressant drugs on wild-type and mature spermatozoa in vitro did not affect sperm motility. It also did not have an effect on midpiece flexibility. The study concluded that calcineurin was important for still developing sperm but not for the mature sperms.